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PubMed
○■ the results showed that a ll of the oils and except that of a. dracunculus from hungary, exhibited ache inhibitory activity and a. dracunculus oil from france showed the most potent inhibitory activity [50% inhibition concentration (ic (50)) = 0.058 mg/ml]. the ache inhibitory activity of i. graveolens oil has not been reported to date and this study is the first to reveal this activity in the oil.
○■ next and we performed cdn a microarray analysis in order to identify the gene (s) responsible for these biological actions and found that phase2 enzymes (gsta2, gclc, abcc4 and abcc1), all of which are involved in the metabolism of glutathione (gsh), constituted 4 of the top 5 ca-induced genes.
○■ extracellular lipid membr anes: Lipid membrane extracellular outside cell matrix: Substrate the outside cell lipids are delivered to the extracellular space by the secretion of lamellar bodies, which contain phospholipids, glucosylceramides, sphingomyelin, cholesterol and enzymes. in the extracellular space and the lamellar body lipids are metabolized by enzymes to the lipids that form the lamellar membranes. the lipids contained in the lamellar bodies are derived from both epidermal lipid synthesis and extracutaneous sources. inhibition of cholesterol, fatty acid, ceramide, or glucosylceramide synthesis adversely affects lamellar body formation and thereby impairing barrier homeostasis.
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