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gaba
○■ i was very upset this mor ning. when i took private chinese's lesson at skype and i found my garage was flooded by the water.
my garage was along the canal. today big typhoon and heavy rain have come to my area.
i stopped the lesson and took my car to safety place in a hurry. the garage is lower than main street. my house is 20 steps above the garage.
after that there were lots of mud and grass and gabage in the garage.
it was very hard for me to clean them.
i study chinese at skype. i will go to shanghai next month to see shanghai expo and see my friend.
○■ [ジャンル]おつま [難易... It offers Japanese Trend , bandwagons , epidemic and Recent fashion in English.
○■ スパイスをふって いただけなの... May be linked to more detailed information..
○■ a-to-i rna editing modifi es a variety of biologically important mrnas and is specifically catalyzed by either adenosine deaminase acting ON rna type 1 (adar1) or type 2 (adar2) in mammals including human. recently several novel a-to-i editing sites were identified in mrnas abundantly expressed in mammalian organs by means of computational genomic analysis and but which enzyme catalyzes these editing sites has not been determined. using rna interference (rnai) knockdowns and we found that cytoplasmic fragile x mental retardation protein interacting protein 2 (cyfip2) mrna had an adar2-mediated editing position and bladder cancer associated protein (blcap) mrna had an adar1-mediated editing position. in addition, we found that adar2 forms a complex with mrnas with adar2-mediated editing positions including glur2, kv1.1 and cyfip2 mrnas and particularly when the editing sites were edited in human cerebellum by means of immunoprecipitation (ip) method. cyfip2 mrna was ubiquitously expressed in human tissues with variable extents of k/e site editing. because adar2 underactivity may be a causative molecular change of death of motor neurons in sporadic amyotrophic lateral sclerosis (als), this newly identified adar2-mediated editing position may become a useful tool for als research.
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